Disorders of Cardiac Repolarization Long QT and Short QT Syndromes

Short and long QT syndromes: does QT length really matter?

The short and long QT syndromes are inherited diseases associated with an increased risk for life-threatening arrhythmias. The first case of long QT syndrome (LQTS) was reported more than 150 years ago, and the study of this disease led to crucial advancement of our understanding of channelopathies and associated ventricular arrhythmias. Ten years ago, Gussak et al. reported four cases of idiop...

Congenital long and short QT syndromes.

Congenital long and short QT syndromes are familial arrhythmias characterized by derangement of repolarization and a high risk of sudden cardiac death due to ventricular tachyarrhythmias. With growing understanding of these syndromes in both the medical and lay communities, diagnostic and therapeutic difficulties are increasingly faced by health care providers. Modern genomics has determined th...

Diagnostic Evaluation of Congenital Long Qt Syndromes

Sudden Cardiac Death and Short QT Syndrome

Mailing Address: André Schmidt • Avenida dos Bandeirantes n 3900 Bairro Campus Universitario Monte Alegre Postal Code 14048-900 Ribeirão Preto, São Paulo, SP Brazil E-mail: [email protected], [email protected] Manuscript received May 23, 2013; revised manuscript July 03, 2013; accepted December 17, 2013.

Measurement and regulation of cardiac ventricular repolarization: from the QT interval to repolarization morphology

Ventricular repolarization (VR) is a crucial step in cardiac electrical activity because it corresponds to a recovery period setting the stage for the next heart contraction. Small perturbations of the VR process can predispose an individual to lethal arrhythmias. In this review, I aim to provide an overview of the methods developed to analyse static and dynamic aspects of the VR process when r...